Intensive care

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Air leak test in the Paediatric Intensive Care Unit (ALTIPICU): rationale and protocol for a prospective multicentre observational study

Boris Lacarra, Aurélie Hayotte, Jérôme Naudin, Arielle Maroni, Guillaume Geslain, Géraldine Poncelet, Michael Levy, Matthieu Resche-Rigon, Stéphane Dauger

30 April 2024

Metformin for sepsis-associated AKI: a protocol for the Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis-associated AKI (LiMiT AKI)

Ivan E Saraiva, Natsumi Hamahata, David T Huang, Sandra L Kane-Gill, Ryan M Rivosecchi, Sruti Shiva, Thomas D Nolin, Xinlei Chen, John Minturn, Chung-Chou H Chang, Xiaotong Li, John Kellum, Hernando Gómez

30 April 2024

Healthcare and economic cost burden of emergency medical services treated non-traumatic shock using a population-based cohort in Victoria, Australia

Jason E Bloom, Emily Nehme, Elizabeth Davida Paratz, Luke Dawson, Adam J Nelson, Jocasta Ball, Amminadab Eliakundu, Aleksandr Voskoboinik, David Anderson, Stephen Bernard, Aidan Burrell, Andrew A Udy, David Pilcher, Shelley Cox, William ChanSee the full list of authors

28 April 2024

Effect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage: protocol for a multicentre, randomised controlled trial (HerpMV)

Stefan Hagel, Nicole Brillinger, Sebastian Decker, Maria Deja, Christian Ertmer, Sandra Fiedler, Philipp Franken, Markus Heim, Markus A Weigand, Alexander Zarbock, Mathias W Pletz, , SepNet Critical Care Trials Group, Johannes Ehler, Frank BloosSee the full list of authors

25 April 2024

Safety of different concentrations of glycerine enema for meconium evacuation in preterm infants: study protocol for a randomised controlled trial

Xia Li, Changhong Liu, Jing Zhang, Qingling Yu, Xuemei Guo, Yanling Hu, Jing Shi

23 April 2024

Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial

Daniel Thomas-Rüddel, Michael Bauer, Luís Ferreira Moita, Christiane Helbig, Peter Schlattmann, Johannes Ehler, Tim Rahmel, Patrick Meybohm, Matthias Gründling, Heiko Schenk, Thomas Köcher, Frank M Brunkhorst, Markus Gräler, Ann-Julika Heger, Sebastian WeisSee the full list of authors

22 April 2024

Restrictive use of Restraints and Delirium Duration in the Intensive Care Unit (R2D2-ICU): protocol for a French multicentre parallel-group open-label randomised controlled trial

Romain Sonneville, Camille Couffignal, Florian Sigaud, Virginie Godard, Juliette Audibert, Damien Contou, Adam Celier, Michel Djibre, Julien Schmidt, Pierre Jaquet, Armand Mekontso Dessap, Claire Bourel, Romane Bellot, Carine Roy, Fariza LamaraSee the full list of authors

17 April 2024

Development of an enhanced scoring system to predict ICU readmission or in-hospital death within 24 hours using routine patient data from two NHS Foundation Trusts

Marco A F Pimentel, Alistair Johnson, Julie Lorraine Darbyshire, Lionel Tarassenko, David A Clifton, Andrew Walden, Ian Rechner, Peter J Watkinson, J Duncan Young

12 April 2024

Association of antibiotic duration and all-cause mortality in a prospective study of patients with ventilator-associated pneumonia in a tertiary-level critical care unit in Southern India

Nivin Daniel Stanley, Jonathan Arul Jeevan, Bijesh Yadav, Karthik Gunasekaran, Kishore Pichamuthu, Vignesh Kumar Chandiraseharan, Sowmya Sathyendra, Samuel George Hansdak, Ramya Iyyadurai

11 April 2024

Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial

Leanne M Aitken, Lydia M Emerson, Kalliopi Kydonaki, Bronagh Blackwood, Benedict Creagh-Brown, Nazir I Lone, Cathrine A McKenzie, Michael C Reade, Christopher J Weir, Matt P Wise, Timothy S Walsh

5 April 2024

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