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Haematology (incl blood transfusion)

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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimus-based post-transplant cyclophosphamide (Methods of T cell Depletion, MoTD trial)
Ronjon Chakraverty, Emma Kempshall, Fiona Dignan, Adrian Bloor, Matthew Collin, Kavita Raj, Jeff Davies, Victoria Potter, Ram Malladi, Siobhan Smith, Simon Gates, Charlotte Gaskell, Rebecca Bishop, Andrea Hodgkinson, Gabrielle Smith

28 January 2025

Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study)
Jerome Stirnemann, Jacques Serratrice, Tamara Mann, Pierre Louge, Combescure Christophe, Kaveh Samii, Rodrigue Pignel, Thomas Agoritsas, Marc Ansari, Giovanna Cannas, Yves Chalandon, Laurent Cimasoni, Pierre Cougoul, Benoit Desgraz, Alain GervaixSee the full list of authors

28 November 2024

Identifying thresholds for meaningful improvements in NTDT-PRO scores to support conclusions about treatment benefit in clinical studies of patients with non-transfusion-dependent beta-thalassaemia: analysis of pooled data from a phase 2, double-blind, placebo-controlled, randomised trial
Ali T Taher, Khaled M Musallam, Vip Viprakasit, Antonis Kattamis, Jennifer Lord-Bessen, Aylin Yucel, Shien Guo, Christopher G Pelligra, Alan L Shields, Jeevan K Shetty, Mrudula B Glassberg, Luciana Moro Bueno, Maria Domenica Cappellini

14 November 2024